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Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis

It is conceivable that a well-defined proneurogenic lifestyle could delay the occurrence of neurodegeneration associated with aging or even improve the status of neurodegenerative patients

Njoku DB, Li Z, Washington ND, Mellerson JL, Talor MV, Sharma R, et al