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A study carried out in healthy adolescents, with a much wider age range among the subjects, ruled out the role of confounding variables, such as diabetes, medications, and age, in the association between GSH and 25(OH)VD

Moreover, the authors demonstrated that SARS-CoV-2 infection could increase the blood-brain barrier permeability by downregulating as well as remodeling the intercellular tight junction proteins

Although the data provide valuable information about the molecular mechanisms by which uric acid affects vascular cell function, further studies are needed to explore p53 and oxidative stress pathways in vascular diseases

Articles published prior to 2000 were not included, nor were non-human studies (such as animal or in vitro models), case reports, reviews, editorials, commentaries, or conference abstracts with incomplete data, studies with no renal outcomes or with insufficient data for extraction, duplicate publications, or studies with overlapping data