Escalation phase breakdown The standard protocol starts low and increases every four weeks to minimize gastrointestinal side effects that rapid dose escalation can cause
Rosito M, Maqbool J, Reccagni A, Giampaoli O, Sciubba F, Antonangeli F, Scavizzi F, Raspa M, Cordella F, Tondo L, et al
Moreover, metabolic reprogramming in immune cells, particularly mitochondrial dysfunction, has been linked to enhanced immune responses and tissue damage in SLE, further highlighting the role of hypoxia in driving autoimmune pathology (149)
HPLC mobile phase 10% v/v ACN in water a serum blank experiment to detect any interfering peaks in the HPLC chromatogram was performed by in an identical manner except that no drug was added