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Nevertheless, few studies have specifically addressed its therapeutic potential in the prevention or treatment of disorders associated with smooth muscle dysfunction

Additionally, MSC-derived exosomes enriched in miRNAs such as miR-21 downregulate apoptotic regulators including PTEN and PDCD4, activate the PI3KAkt survival pathway, and alleviate oxidative stress [25]

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Anecdotal reports from Phase 2 participants suggest that nausea severity is higher when dosing occurs in the early morning on an empty stomach, possibly because fasting amplifies the compound's gastric-slowing effect