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13,179 Free testosterone can be measured directly, or indirectly by means of a calculation from measurements of total testosterone and SHBG

This distinction is important because endoscopic therapy may be considered for T1a disease, given the low risk of metastatic lymphadenopathy (2%) compared with submucosal disease, for which the risk of metastatic lymphadenopathy is 20% to 30%, and the therapy of choice is esophagectomy (which allows lymph node dissection and removal) in operative candidates

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