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Figure 1 To determine whether cell death follows the pattern of superoxide levels recorded in DPI and MitoQ-treated IMR-5/75 cells, cell toxicity was measured using the CellTox Green Dye that detects modifications in membrane integrity resulting from cell death ( Figures 1A, C )

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While FAs are essential metabolic substrates used for cellular energy, in excess, FAs can have deleterious effects through the buildup of toxic lipid metabolites (8) in a condition known as lipotoxicity (9)