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In recent years, a large body of evidence has shown that protective autophagy, cell cycle regulators, and some transcription factors play a key role in tamoxifen resistance, such as KLF4 regulating drug resistance by regulating MAPK and the discovery of LEM4 ( In this review, the development of tamoxifen resistance in breast cancer is discussed, with special emphasis on the effects of some newly discovered enzymes and transcription factors on tamoxifen resistance, the protective autophagy of cells, and the latest progress in cell cycle regulators

11 3 Causes of Female Infertility The causes of fertility problems in women can be categorized as ovulation dysfunction, tubal infertility, uterine and cervical issues, and diminished ovarian reserve

2.4.4.4 Mass spectrometry conditions The mass spectrometry parameters are shown in Table 2