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320 2 g) and 1, 5, 10, 15 and 20 min after injection of fentanyl (75 g/kg, IV)

In parallel, GHK-Cu stimulates angiogenesis formation of new capillaries, which improves microcirculation and dermal nutrition

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In order to improve outcomes, biphasic scaffolds can be created with a softer upper layer containing chondrogenic factors (e.g., TGF-, chondroitin sulfate) and a stiffer lower layer, often loaded with calcium phosphate, hydroxyapatite, or bone morphogenetic protein (BMP), to provide structural support of the above cartilage layer and to promote osteogenic tissue formation and boney integration