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Retatrutide is an investigational triple-agonist peptide designed to activate: GLP-1 (Glucagon-Like Peptide-1) receptors GIP (Glucose-Dependent Insulinotropic Polypeptide) receptors Glucagon receptors By targeting all three pathways, retatrutide addresses appetite regulation, insulin resistance, energy expenditure, and fat metabolism together rather than focusing on appetite suppression alone

doi:10.1161/CIRCRESAHA.119.316306 151

HTyr metabolites also inhibit amyloid- deposition in cellular models (40)

Although automated image analysis techniques require further refinement, these imaging advances not only deepen our understanding of ferroptosis-related mechanisms in AD but also lay the groundwork for developing early diagnostic and targeted therapeutic strategies (181, 182)