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Rojo et al., 2014) and inducible nitric oxide synthase (iNOS) (Rojo et al., 2014) facilitate rapid generation of superoxide radicals and nitric oxide (NO) aiding in pathogen elimination and contributing to neuroinflammation during aberrant activation

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Thus, targeting the NRF2-ARE axis can provide long-lasting and comprehensive neuronal protection, rendering it highly attractive for the treatment of neurodegenerative diseases