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The combination of the lysosome disruptor siramesine and the tyrosine kinase inhibitor lapatinib increased the expression of TF and reduced the expression of FPN1 in breast cancer cells, thereby promoting iron overload in the lysosome and ultimately inducing ferroptosis (Ma et al., 2016)

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Vitamin B12 deficiency affects a measurable portion of the population

The intracellular concentrations of vitamin B12 can be inferred through the total plasma concentration of homocysteine, which can be converted to methionine through an enzymatic reaction that uses 5-methyltetrahydrofolate as the methyl donor group