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Concomitant with these changes were increases in antioxidant proteins such as CP and HO-1, likely a natural protective mechanism to manage the mounting oxidative stress load

COVID-19 Cell Atlas , Chan Zuckerberg Biohub & Stanford University

H2O2, although not a radical, can be converted into the highly reactive hydroxyl radical through Fenton or Haber-Weiss reactions, particularly in the presence of transition metals such as iron or copper [27]

Overall, ROS accumulation in conjunction with declining antioxidant defenses may contribute to oocyte and granulosa cell dysfunction and influence the aging trajectory of the follicular microenvironment