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Importantly, regulatory mechanisms of FECH activity are integrated in the context of its integration in the heme metabolon (Medlock et al., 2015)

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Abbreviations AD Alzheimers disease AEDs antiepileptic drugs ARE antioxidant response elements CNS central nervous system Cys cysteine SLC7A11 cystine/glutamate antiporter solute carrier family 7 member 11 CoQ10 coenzyme Q10 DFO deferoxamine DCYTB duodenal cytochrome B reductase FSP1 ferroptosis suppressor protein 1 FeCl 3 ferric chloride DMT1 divalent metal transporter 1 GSH glutathione GSR glutathione reductase GPX4 glutathione peroxidase 4 Glu glutamate Gly glycine HCP-1 heme carrier protein-1 HO-1 heme oxygenase 1 OH hydroxyl radical H 2 O 2 hydrogen peroxide HS hippocampus sclerosis IREB2 iron-responsive element-binding protein 2 KA kainic acid Keap1 Kelch-like ECH-associated protein 1 MTLE mesial temporal lobe epilepsy Nrf2 nuclear factor erythroid 2 related factor 2 NCOA4 nuclear receptor co-activator 4 PD Parkinsons disease PTE post-traumatic epilepsy ROS reactive oxygen species RNS reactive nitrogen species TBI traumatic brain injury O 2 superoxide anion STEAP3 six-transmembrane epithelial antigen of prostate 3 SIRT3 Sirtuin3 SAH subarachnoid hemorrhage TLE temporal lobe epilepsy TF transferrin TFR1 transferrin receptor-1