Therefore, there is a need for well-designed, large-scale, long-term RCTs in healthy adults, in individuals with micronutrient deficiencies, as well as in children an age group undergoing rapid cognitive and brain development
When cellular glutathione levels drop, the accumulation of unneutralized reactive oxygen species provokes mast cells to become hyper-reactive, inappropriately releasing massive quantities of histamine into the bloodstream
Park EY, Shimura N, Konishi T, et al
As an excitatory neurotransmitter, high level of glutamate can alter the strength of certain groups of glutamatergic synapses in a variety of brain regions, such as the prefrontal cortex (PFC), hippocampus, and nucleus accumbens (NAc), causing dysfunction of cortico-mesolimbic reward circuitry that underlies many manifestations of depression (52)