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Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

Since gene expression is dependent on the epigenetic markers on gene promoters, which mediates either repression or induction of genes transcription, one possibility may be through manipulating the epigenetic markers on the promoters of the TFs genes that regulate neurogenesis in the adult brain