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& Jayaraman, S

In some embodiments, the formulations or compositions described herein have a pH between about 3 and about 9, or between about 4 and 8, or between about 5 and 8, or between about 6 and about 7, or between about 6.5 and about 7, or between about 5.5 and about 7.5, or between about 7.1 and about 7.7, and have a concentration of active pharmaceutical ingredient between about 0.1 mM and about 100 mM

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Interestingly, the observation that other amino acids than V12 and F112 can principally support flavonoid binding is also reflected in the more relaxed amino acid conservation in native arGSTFs at these two positions (Fig