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On the other hand, there is evidence that spinal cord injury triggers a cascade of secondary degenerative events that cause further damage to the injured area and induce local inflammation along with hemorrhage and edema [12, 13] and that the therapeutic agents imatinib (which has been shown to inhibit cytokine production and reduce hemorrhage, edema, and inflammation) [14] and ibuprofen initiate favorable axonal growth and functional recovery through Rho inhibition [15]

Therefore, publication bias is unlikely to have a major impact on the overall findings of this meta-analysis

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