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The discrepancy was reduced when restricting to the 195 participants with both survey and EHR data, but remained significant (self-report = 14.14% versus 8.43% in EHR, P = 1.1 10 9 paired t -test

The intracellular signaling cascades activated during dosing PI3K/Akt/mTOR for synthesis, FoxO suppression for anti-catabolism do not terminate immediately when plasma LR3 clears (Yoshida & Delafontaine, 2020)

Genetic and metabolic studies may provide additional clues to specific etiologies or treatments, but there are no generally accepted biological markers for commonly affected cellular pathways in ASD