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Recently, a mimetic peptide of TSP-1 called 4N1Ks has been developed as a senolytic therapy and confirm the high interest to investigate CD47 pathway in senescence 48

have shown that the activation of STAT3 in Tregs endows them with the ability to suppress T H 17 responses through increasing the expression of a subset of suppressor molecules ( H 17 cells seems to lead to a different outcome regarding the net activation of T H 17 cells