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The BTB domain binds Cul3, contains the Cysteine151 residue (C151), which is one of the important cysteine residues in stress sensing, and mediates KEAP1 homodimerization [123,124,125]

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indeed, they are strongly involved in cell death pathways, such as apoptosis, necrosis, and autophagy 32 , which cause an important portion of neuronal damage in the perinatal HI event (Fig

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