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According to the FDA, tobacco naturally contains several harmful chemicals, including but not limited to: Nicotine Lead Cadmium Nitrates Trace fertilizers The FDA reports that these natural chemicals can be harmful if ingested, smoked or chewed, stating that as the plants grow, the concentration of harmful chemicals builds up and concentrates in the leaves

No significant changes in cigarette use were found in the controls

Yes, it can happen with high thc cannabis

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