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2.2 PICOs question The primary research question addressed in this review was: What is the effectiveness of sublingual/oral administration of Vitamin B12 alone or compared to other forms of administration (e.g., intramuscular injection)?

But she felt like the wool had been pulled over her eyes. Most older adults get enough vitamin B12 from their diet, as long as it includes a reasonable amount of lean meat, Zimmerman says

Pharmacokinetic Optimization strategies Dosage form improvement Develop sustained-release preparations to reduce injection frequency and enhance patient compliance