Reported benefits (per available research): FDA-approved, clinical-trial-supported reduction of excess visceral abdominal fat in HIV-associated lipodystrophy, the only indication with robust human RCT evidence behind it Studied in a randomized, placebo-controlled trial for possible support of executive function and cognitive performance in healthy older adults and adults with mild cognitive impairment (Baker et al., 2012) Proposed, but far less rigorously studied in healthy or bodybuilding populations, to support lean body mass and body composition changes through GH/IGF-1 axis stimulation
Many women report not just better focus, but a return to themselves feeling mentally present, motivated, and emotionally balanced again
Evidence for local versus systemic injection effectiveness remains debated
The effects of Vitamin B12, a key component, can last for several days to a week, but this can vary depending on how quickly an individuals body uses or excretes it