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[DOI] [PMC free article] [PubMed] [Google Scholar] 192.Tsoi K.M., Dai Q., Alman B.A., Chan W.C

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You may be more likely to experience histamine intolerance if you have an MTHFR gene variation.5 Histamine intolerance can be understood as your body struggling to manage too much histamine, a substance it naturally uses to function.6 Think of it like trying to fit too much into a 5-gallon bucketif you overfill it, things spill out and cause issues