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Key finding: AOD 9604 reduced cartilage damage score by 67%, decreased MMP-13 activity by 58%, and preserved joint space width

40,43,44,45 Furthermore, glutamine and cysteine metabolism are deeply linked, 46,47 because serine and glycine can derive from glutamine and, by entering the one-carbon metabolism pathway, they will contribute to homocysteine and cysteine syntheses