Unlike normal HSCs, CML cells are highly dependent on OxPhos regulated by sirtuin 1 (SIRT1)-mediated activation of peroxisome proliferator-activated receptor coactivator 1 (PGC1) (4951)
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Standard rapid-release formulas, even if absorbed, create a brief spike in blood levels followed by a rapid crash, whereas sustained-release formulations maintain a therapeutic window that provides round-the-clock cellular protection
Savas, C., Ozguner, M., Ozguner, F