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Upon modification of the protein with the covalent nucleotide analogs, no nucleotide exchange was observed for compounds 7a and 7b , including the linear and cyclic linkers, respectively, that showed the highest reactivities in the previous experiments

In contrast, the United States regulates probiotics under multiple pathways (foods, dietary supplements, drugs, biologics), using Generally Recognized As Safe (GRAS) notices for food uses and more demanding drug/biologic pathways for LBPs intended to treat or prevent disease (521)

Bacteria were incubated for 3 days shaking at 37 C

DOI: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-032-00788-9 Online ISBN: 978-3-032-00789-6 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)