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Glutathione, by preventing protein oxidation, may interrupt this cycle at its earliest stage - before the autoimmune cascade is triggered or amplified

Similarly, rapamycin reduces seizures by inhibiting mTOR, a kinase that mediates positive feedback to the VEGF pathway, which decreases BBB leakage and reduces activation of microglia and macrophages (182)

doi:10.1002/dta.2152