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Consequently, the cytosolic probe for confocal imaging was changed to coumarin chloroalkane (Comcl), which fluoresces in a distinct spectral window, thereby enabling clear spatial separation of cytosolic and periplasmic signals

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p 1 year of treatment with ritlecitinib to achieve response (late responders), highlighting the importance of extending treatment duration.20 Subgroup analyses This study was not powered to test hypotheses in subgroups such as adolescents or patients with AT or AU