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In total, nine treated patients had significantly reduced discomfort and improved tear volume production, even 28 days following treatment

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The method of any one of embodiments 118-137, wherein the composition comprises between about 0.0001% to about 20% by weight of the therapeutic agent, about 0.0001% to about 15% by weight of the therapeutic agent, about 0.0001% to about 10% by weight of the therapeutic agent, about 0.0001% to about 5% by weight of the therapeutic agent therapeutic agent, or about 0.0001% to about 1% by weight of the therapeutic agent

Upper Arm Injections and Rotation Strategy The upper arm is a valid third option, though it typically requires another person to administer the injection because reaching that area yourself consistently can be awkward