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At the physiological phenotype level, CRISPRa has also been used to increase the transcription of obesity risk genes SIM1 and MC4R , and to successfully rescue haploinsufficient obesity in mouse modelswith the effects persisting up to 9 months post-treatment [80]

You're introducing a significant variablepotential contamination or a degraded preservativethat has no place in controlled research

This means use is limited to in-vitro laboratory testing and experimentation in qualified research institutions

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