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At a Glance: How They Compare For those seeking a quick answer, here is how these two powerhouses stack up: The Retinol Approach: The Great Resurfacer Retinol, a derivative of Vitamin A, has long been the "go-to" for anti-aging

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Many patients reduce their dose or quit entirely because of GI discomfort

The tolerogenic mechanism is elegant: by presenting histone epitopes in a context that promotes regulatory rather than effector T cell responses, these peptides essentially re-educate the immune system to tolerate its own nuclear components