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Let's let the researchers phrase it: The endocannabinoid (eCB) system has emerged as a central integrator linking the perception of external and internal stimuli to distinct neurophysiological and behavioral outcomes (such as fear reaction, anxiety, and stress-coping), thus allowing an organism to adapt to its changing environment

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In fact, the profound ROS accumulation characteristic of sickle RBCs has been demonstrated to be mainly caused by NADPH oxidase, which is regulated by Rac GTPase [179]