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43 The relevance of this pathway for tumorigenesis is demonstrated by the fact that humans with the Laron syndrome, a recessively inherited defect in the growth hormone receptor, display extremely low IGF-1 and reduced insulin concentrations and usually do not develop cancer despite high prevalence of obesity and dyslipidemia

Cell Metab 25:2742 [DOI] [PMC free article] [PubMed] [Google Scholar] Elesawy BH, Raafat BM, Muqbali AA, Abbas AM, Sakr HF (2021) The impact of intermittent fasting on brain-derived neurotrophic factor, Neurotrophin 3, and rat behavior in a rat model of type 2 diabetes Mellitus

The results of those studies show the following

This increased binding may well be attributed to an increased surface area of the microspheres compared to homogenates, but further experiments would be needed to test this hypothesis