For example, specific gene polymorphisms have been linked to variations in depressive symptoms in response to major life stress, underscoring the important role genetic factors play in the disorders pathogenesis [302, 303]
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Collectively, these findings suggest that distinct HIF subtypes are expressed in various synovial cell types, all of which participate in the occurrence and progression of RA
C-Src is yet another pathway that control various biological functions where its aberrant regulation can lead to anchorage-independent growth, survival, tumor vascularity, migration, metastasis, survival and invasion [93]
