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Animals and housing Following laboratory animal welfare (3Rs: Replacement, Reduction, and Refinement) best practice [31], we acquired 13 adult female mice (C57BL/6 background) from another lab which were excess to experimental requirements, experimentally nave, and slated for euthanasia

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Glutathione supplementation may support general health and lower risk factors linked to heart disease by limiting chronic oxidative stress

Key molecular mechanisms include mitochondrial reverse electron transport activation induced by mutant proto-oncogenes KRAS/BRAF [385], oxidative inactivation of DNA repair enzymes leading to mutation accumulation [386], and constitutive activation of NRF2 pathway [387]