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As the liver becomes compromised, it struggles to meet its own glutathione needs and there may be little surplus glutathione secreted into the blood for other organs of the body

Acknowledgements The authors acknowledge support from the University of Cagliari under Open Access funding call for the publication of this work

Concurrently, it led to the upregulation of various key metabolic catalytic enzymes, promoting gluconeogenesis, aspartate and glutamate metabolism, as well as amino acid biosynthesis