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doi: 10.1016/S0022-3999(02)00429-4 193 Ait-BelgnaouiADurandHCartierCChaumazGEutameneHFerrierLet al
The gonadal tissue, with abundance of highly unsaturated fatty acids, high rates of cell division, and variety of testis enzymes results very vulnerable to the overexpression of reactive oxygen species (ROS)
In keeping with this idea, the tripeptide L--glutamyl-L-cysteinyl-glycine, or glutathione (GSH), a ubiquitous thiol, plays an important role in maintaining intracellular redox equilibrium and has evolved as one of the major detoxifying antioxidants and abundant thiols in almost all mammalian cells [13, 14, 40, 41, 4750]
These components are considered immunological distractors with pro-inflammatory activity, capable of causing dysbiosis and increased intestinal permeability (the so-called leaky gut syndrome), so favoring the development of autoimmune diseases [142]
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