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Fu SS, Rothman AJ, Vock DM, et al

If you look at the joint effect of all of these characteristics, our model accounts for nearly 4 percent of the variation in nicotine dependence, or nearly four times as much as what we learn when relying solely on a genetic index for the number of cigarettes someone smokes daily, says Rohan Palmer, senior author of the study and assistant professor in Emorys Department of Psychology, where he heads the Behavioral Genetics of Addiction Laboratory

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Fermentation creates heat, which causes fermentation to begin, changing the chemical structure of the tobacco, removing impurities such as ammonia and rendering the tobacco smokeable