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10.1016/bs.apcsb.2019.12.001 306 YaacoubC.WehbeR.RoufayelR.FajlounZ.CoutardB

Primary Ovarian Insufficiency (POI): Also known as premature ovarian failure or premature menopause, this occurs when the ovaries stop functioning normally before the age of 40, leading to a decline in estrogen production and irregular or absent periods

This restoration of metabolic cofactor availability enables enhanced function of NAD+-dependent enzymes including sirtuins, poly(ADP-ribose) polymerases, and various deacetylases that regulate cellular metabolism, stress responses, and aging processes

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