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As such, the ability of GSHee to overcome the fentanyl-induced increase in A-a gradient is most likely due to the direct GSHee-induced increase in Ve and potentially by interfering with any of the other mechanisms described immediately above

2.3 Mechanisms underlying POI POI can arise from a variety of mechanisms, although idiopathic cases, those with no clearly identifiable cause, represent the vast majority, accounting for 85%90% of instances ( 2.3.1 Cellular senescence and release of SASP factors Senescence in granulosa and stromal cells leads to the release of pro-inflammatory and matrix-degrading molecules collectively termed the senescence-associated secretory phenotype (SASP) ( Importantly, SASP may not merely be a byproduct of aging, but a driver of it, contributing to a self-reinforcing loop of tissue deterioration, follicular dysfunction, and reproductive failure

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