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Engineered pigs carrying a gain-of-function NLRP3 homozygous mutation can survive to adulthood and accurately recapitulate human systemic spontaneous inflammatory responses

Both epidermis-specific Mll4- knockout mice and Alox12b loss-of-function mutant mice exhibited epidermal hyperproliferation, scaling, and other cutaneous manifestations similar to ichthyosis, as well as a deficiency of ALOX12b expression in the epidermis of both mice

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