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No finished-drug approval, no active IND, and no FDA-registered human clinical trials as of April 2026

Immaturity of the developing CNS, a larger head-to-body ratio, thinner cranial bones, reduced development of neck and shoulder musculature, a larger subarachnoid space in which the brain can move, and differences in cerebral blood volume have been proposed as possible sources of increased susceptibility to concussions for youth relative to adults (Karlin, 2011