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Although the endometrium is a self-regenerating tissue, evidence points to senescence over time in the individual cellular compartments

The copper concentration used in experiments critically influences cellular responses: low levels (0.10.1.2mmol/l) induce physiological/adaptive transcriptional changes, while higher levels (0.4-0.4.6mmol/l) trigger toxic, stress-related responses [24]

An example of the letrozole spectrum is shown in Figure 4

While pharmacological treatments remain the standard of care, there is growing interest in adjunctive non-pharmacological strategies, including dietary and lifestyle modifications