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seven in absentia homolog 2 (SIAH2), a key regulator, together with hypoxia-inducible factor 1 alpha (HIF-1), of the cellular hypoxic responses under pathological conditions such as ischemia-reperfusion, whose association with NRF2 causes the degradation of NRF2 irrespective of its phosphorylation status [230]

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Importantly, 98% of gastrointestinal events are mild or moderate, 99.5% are non-serious, and only 4-10% of users discontinue therapy due to side effects