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The side effects were most commonly gastrointestinal disturbances such as nausea and vomiting and occurred in a similar frequency to those reported with dual receptor co-agonists [61]

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These were, i.e., in the cerebellum (ibuprofen [107], paracetamol [61]), the cerebral cortex (diclofenac [106,108], celecoxib [105]), the frontoparietal cortex (concussive brain trauma) [78], the hippocampus and the cerebral cortex (insulin) [62], and the parietal neocortex and hippocampus (cuprizone [80]) (note, cuprizone application [80] was an extremely high regimen highly over those commonly applied to mimic multiple sclerosis in rats [268,269])

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