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Rare mutations in this transporter (SLC52A2 gene) cause Brown-Vialetto-Van Laere syndrome, which is a rare neurological disorder that may be helped by riboflavin supplementation in some cases.[ref] MTHFR and vitamin B2 benefits: The MTHFR gene codes for the enzyme needed to convert folate to methylfolate, a key component in the methylation cycle

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However, IV therapy may not be appropriate for everyone

Additionally, accumulation of sorbitol and fructose increases osmotic pressure, leading to membrane permeability and edema [284]