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Learn more: #PIPsignaling #Phosphoinositides #LipidResearch #DrugDiscovery To view or add a comment, sign in PUBLICATION ALERT Recent shifts of checkpoint inhibitors to the neoadjuvant setting allows to deeply investigate the mechanism-of-action of immune therapy with molecular imaging AND tissue analysis

While both agents induce senescence, doxorubicin-induced SCs exhibit a pro-inflammatory, NF-B-driven SASP, whereas CDK4/6i-induced SCs display a less inflammatory, p53-driven SASP, which supports immune surveillance

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