Possible reasons include changes in illness severity, adherence, metabolism, sleep, hormones, inflammation, vitamin D, zinc/B6 status, copper balance, elevated SAH, toxic burden or medication interactions
Furthermore, in a study of NA supplementation with a dose of 207.5 mg NA per day for 32 days to older adults with impaired physical function, no improvements in NAD + or mitochondrial functions in skeletal muscle were observed 321
The choice depends on the specific research question and tissue type
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