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In rabbits and cynomolgus monkeys administered semaglutide during organogenesis, early pregnancy losses and structural abnormalities were observed at below the MRHD (rabbit) and 5-fold or greater the MRHD (monkey)

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The Neh2 domain, which contains ETGE and DLG motifs, is pivotal for Keap1 binding and ubiquitination, whereas the Neh1 domain features a basic leucine zipper (bZIP) structure essential for DNA binding and dimerization with small Maf proteins [17]

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